THE RESEARCH CENTRE

 

The Deb Bailey Foundation Research Centre is located at the Australian School of Advanced Medicine (ASAM) at Macquarie University and is a designated concentration of research excellence in neuroscience.

 

Located at Australian School of Advanced Medicine (ASAM) at Macquarie University, The Deb Bailey Foundation Research Centre is a designated concentration of research excellence in neuroscience, vascular science, surgery and genetics and infection. Macquarie University’s neuroscience expertise integrates research across degenerative neurological diseases such as MND, cardiorespiratory, pain and visual sciences.

 

Macquarie University built Australia’s most technologically advanced hospital on a university in 2010 – Macquarie University Hospital. It works in partnership with the ASAM to deliver Macquarie University with a unique model to undertake “bedside to laboratory” medical research. Macquarie University Hospital is one of the most digitally integrated of its class with the latest unrivalled technologies, much of which is not available anywhere else in Australia.

 

Macquarie University Hospital and ASAM work together to conduct research into best clinical practice. Their research is based on the concept of translational research, a process of adapting scientific discoveries to become practical improvements in patient care at the bedside. ASAM currently has a prestigious research centre with 70 PHD students working alongside a team of leading scientists.

 

Macquarie University Hospital has one of Australia’s largest MND clinics, run by Professor Dominic Rowe. Rowe has a specific interest in researching MND, in particular biomarkers of neurodegenerative diseases, imaging of MND and predictors of progression and severity in MND. He believes that only with insight into the biological processes of these diseases that therapeutic control and perhaps cures of these problems will be identified.

 

 

The Deb Bailey Foundation Research Centre brings MND research teams together, allowing cohesive and collaborative research to ultimately find a cure for MND.

 

The collaboration and partnership of the Deb Bailey Research Centre teams, MND Clinic and Macquarie University Hospital are working towards identifying potential biomarkers and therapeutic approaches for MND.

 

Through this example, the clear synergies of the Deb Bailey Research Centre are demonstrated. They align to provide a research pipeline from clinic to laboratory and back to the clinic. This is supported by a critical mass of leading researchers and collaborative research teams that exists in the new MND Centre.

 

Through our research we want to achieve the following:

    • Develop a more effective model of research that has enhanced ability to achieve breakthrough discoveries in MND research. This collaborative model is more cost effective, and more likely to succeed than individual research teams working in isolation.
    • Understand what causes MND and use this information to develop new therapeutic strategies for MND.
    • Train high quality PhD students and postdoctoral fellows, to build the next generation of MND researchers.

 

Collectively, we have undertaken a careful and targeted recruitment to form a research pipeline that goes from MND clinic to human genetics to cell biology and biochemistry to animal models of MND (zebrafish and mice) to pre-clinical testing.

 

The collaboration and partnership of the Deb Bailey Research Centre teams, MND Clinic, and Macquarie University Hospital:

 

Step 1: MND clinic and Professor Rowe provide samples from a MND patient to the Deb Bailey Research Centre.

Step 2: Associate Professor Blair and his team analyse the patient’s DNA and identify a mutation in gene X that causes MND.

Step 3: Professor Chung and Associate Professor Atkin undertake biochemical studies to understand how the mutation causes the protein produced by gene X to aggregate and cause MND.

Step 4: Professor Chung, Associate Professor Blair and Associate Professor Atkin use a range of cellular techniques to grow motor neurons in vitro and understand how gene X / protein X causes MND.

Step 5: Professor Guillemin investigates how gene X / protein X causes activation of the immune system and what toxic neurochemicals cause MND.

Step 6: Dr Cole makes zebrafish that express mutated gene X, and investigates how mutations in gene X cause MND.

Step 7: Collectively these studies allow the researchers at the Deb Bailey Research Centre to comprehensively determine how gene X causes MND, and identify potential biomarkers of the
disease and therapeutic approaches.

 

 

Click here to learn more about the Big Questions our research will answer

Click here to read about our Value Proposition for MND patients and their friends and family

Click here to read about our Value Proposition for Government and Community Sponsors

Click here to read about our Value Proposition for Researchers at our Research Centre

 

 

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The Deb Bailey Foundation for Motor Neurone Disease is a not-for-profit organistation and depends on the generosity of individuals, corporations and community groups to help us achieve our mission of finding a cure for MND. Whether your interested in fundraising, sponsorship, joining the research team, or if you’re just keen to get involved, there are many ways you can help.

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You can support the research and work we are doing by donating to The Deb Bailey Foundation for Motor Neurone Inc. Whether it’s a one off donation, pledge or sponsorship you can be assured that your money is going towards research aimed at finding a cure for MND.

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Are you looking to get involved through research, by providing information or by sharing stories about your involvement with MND? If you would like to get in touch with us, The Deb Bailey Centre for Motor Neurone Disease, or our researchers please contact us.

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